https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Going beyond antibiotics: natural plant extracts as an emergent strategy to combat biofilm-associated infections https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40187 Wed 20 Jul 2022 14:17:50 AEST ]]> Nephrotoxicity in rats exposed to paracetamol: the protective role of moralbosteroid, a steroidal glycoside https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32515 M. alba stem bark. Nephrotoxicity was induced with administration of paracetamol. Nephroprotection was studied using two doses of the extract. The experimental animals were divided into four groups (n = 6). Two groups served as positive and negative controls, respectively, and two received the test substances. All of the contents were orally administered. Significant reductions in nephrotoxicity and oxidative damages were observed in the treatment groups. There was a marked decrease in blood levels of urea, creatinine, and lipid peroxidation. Furthermore, it was found that glutathione levels in the blood increased dramatically after treatment. Histological findings confirmed the potent renoprotective potential of moralbosteroid. This was evidenced by the minimized intensity of nephritic cellular destruction. In animal studies, moralbosteroid exhibited dose-dependent activity, which is thought to be mediated through its antioxidant potential.]]> Wed 13 Jun 2018 11:02:23 AEST ]]> Therapeutic potential of artemisia vulgaris: an insight into underlying immunological mechanisms https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44237 Artemisia vulgaris is a traditional Chinese herb believed to have a wide range of healing properties; it is traditionally used to treat numerous health ailments. The plant is commonly called mugwort or riverside wormwood. The plant is edible, and in addition to its medicinal properties, it is also used as a culinary herb in Asian cooking in the form of a vegetable or in soup. The plant has garnered the attention of researchers in the past few decades, and several research studies have investigated its biological effects, including antioxidant, anti-inflammatory, anticancer, hypolipidemic, and antimicrobial properties. In this review, various studies on these biological effects are discussed along with the tests conducted, compounds involved, and proposed mechanisms of action. This review will be of interest to the researchers working in the field of herbal medicine, pharmacology, medical sciences, and immunology.]]> Tue 11 Oct 2022 12:13:02 AEDT ]]> Metformin: a salutary candidate for colorectal cancer treatment in patients with diabetes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46664 Mon 28 Nov 2022 18:32:29 AEDT ]]>